|
KMID : 1144820190250010083
|
|
대한의생명과학회지
2019 Volume.25 No. 1 p.83 ~ p.91
|
|
|
The Ameliorative Effect of Angelica acutiloba Ameliorates Through the NO / iNOS Pathway in Rats with Systemic Allergy
|
|
Cho Min-Seok
Park Hae-Woong
Lee Gil-Hyun
Yoon Hae-Gyung
Oh Kyung-Mo
Choi Seok-Cheol
Hyun Kyung-Yae
|
|
|
Abstract
|
|
|
|
This study was undertaken to investigate the therapeutic effect of Angelica acutiloba on allergic dermatitis, which Angelica acutiloba is traditionally known to have antiinflammatory effects. Sprague-Dawley (SD) rats were divided into five groups: normal control group, experimental allergic dermatitis group (vehicle group), low dose of Angelica acutiloba extract (low-dose group), high dose of Angelica acutiloba extract (high-dose group), and antihistamine treated group with experimental dermatitis (antihistamine group). Total leukocyte, neutrophil, lymphocyte, monocyte and eosinophil counts were significantly higher in the vehicle group than in the control group, but these variables were significantly lower in the low- and high-dose groups than in the vehicle group. The platelet/lymphocyte ratio in the red blood cell index was significantly lower in the low- and high-dose groups than in the vehicle group. Low and high doses of the Angelica acutiloba extract did not have toxic effects on liver and kidney. Serum NO, iNOS and levels were highest in the vehicle group but significantly lower in the low- and high-dose groups, especially in the high-dose group. The results of this study suggested that the Angelica acutiloba extract had the effect of alleviating or treating the experimental allergic dermatitis, and it was concluded that the high dose was more effective.
|
|
|
KEYWORD
|
|
|
Experimental allergic dermatitis, Angelica acutiloba, Total white blood cell, NO, iNOS
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|